Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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STAT5 alters the state of transcriptional networks, driving aggressive leukemia

May 18, 2017

The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA.

RNA-binding proteins, the guardians of the marginal zone

May 18, 2017

RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription...

Alternative monocytes settle in for the long term

May 18, 2017

Monocytes recruited to the peritoneum under conditions of a type 2 inflammatory reaction can convert into resident-type macrophages under the control of vitamin A.