Seung-Chul Choi



Seung-Chul Choi:

Our lab has previously shown that the differential expression of a novel splice isoform, Pbx1-d, of the Pbx1 gene was associated with the production of autoreactive CD4+ T cells in the Sle1a1 lupus susceptibility locus and lupus susceptibility in the B6.Sle1.Sle2.Sle3 mouse model. Currently, we have generated B6.CD4-Pbx1-d Tg (Pbx1-d Tg) mice, which specifically express Pbx1-d in CD4+ T cells, and I am studying the mechanisms by which Pbx1 regulates Treg homeostasis and follicular T cell differentiation in the Pbx1-d Tg mice, as well as its role in autoimmune pathology in the B6.Sle1.Sle2.Sle3 mice.