Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

May 20, 2019

Nature Immunology, Published online: 20 May 2019; doi:10.1038/s41590-019-0386-1Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and...

CD8<sup>+</sup> T cells induce cachexia during chronic viral infection

May 20, 2019

Nature Immunology, Published online: 20 May 2019; doi:10.1038/s41590-019-0397-yCachexia manifests in cancer, chronic inflammation and infections. Bergthaler and colleagues show that CD8+ T cells...

Triggers of inflammation

May 20, 2019

Nature Immunology, Published online: 20 May 2019; doi:10.1038/s41590-019-0410-5Triggers of inflammation

Controlling PD-L1 in <i>cis</i>

May 20, 2019

Nature Immunology, Published online: 20 May 2019; doi:10.1038/s41590-019-0412-3Controlling PD-L1 in cis

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

May 20, 2019

Nature Immunology, Published online: 20 May 2019; doi:10.1038/s41590-019-0396-zHigh-energy diet triggers mild β cell proliferation to compensate for peripheral insulin resistance. Qi and colleagues...