Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

April 1, 2020

Nature Immunology, Published online: 01 April 2020; doi:10.1038/s41590-020-0670-0Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0633-5Autoreactive T cells are subject to continuous antigenic stimulation yet sustain their autoreactive functionality....

The persistence of stemness

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0644-2Epigenetic modifications are associated with distinct stages of autoreactive CD8+ T cell differentiation. DNA...

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0641-5Therapeutic irradiation can trigger DNA-sensing pathways and trigger antitumor immunity. Fu and colleagues demonstrate...

Sestrins induce natural killer function in senescent-like CD8<sup>+</sup> T cells

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0643-3Akbar and colleagues show that sestrins induce the reprogramming of non-proliferative, senescent-like...