Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Denisovan, modern human and mouse <i>TNFAIP3</i> alleles tune A20 phosphorylation and immunity

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0492-0A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human...

Modulation by hypusination

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0508-9Modulation by hypusination

Nuclear viral sensors

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0507-xNuclear viral sensors

Mechanosensing through immunoreceptors

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0491-1Zhu and colleagues discuss the forces that affect the ligand recognition, receptor triggering and signal...

Tolerance factor

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0506-yTolerance factor