Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

May 11, 2021

Nature Immunology, Published online: 11 May 2021; doi:10.1038/s41590-021-00942-0RIG-I is a cytosolic nucleic acid sensor triggering type I IFN production. Takaoka and colleagues find that RIG-I...

Promise and complexity of lupus mouse models

May 10, 2021

Nature Immunology, Published online: 10 May 2021; doi:10.1038/s41590-021-00914-4As a follow up to a 2010 meeting deliberating on the benefits of studying mouse models of systemic lupus erythematosus...

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

May 7, 2021

Nature Immunology, Published online: 07 May 2021; doi:10.1038/s41590-021-00937-xThe innate sensors of SARS-CoV-2 are still being determined. Kanneganti and colleagues find that SARS-CoV-2 envelope...

A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness

May 6, 2021

Nature Immunology, Published online: 06 May 2021; doi:10.1038/s41590-021-00925-1Dick and colleagues identify human LT-HSC subsets with distinct quiescent states. They link these differences to...

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

April 27, 2021

Nature Immunology, Published online: 27 April 2021; doi:10.1038/s41590-021-00922-4Immune cells exert important effects on white adipose tissue (WAT) in metabolic diseases. O’Sullivan and colleagues...