Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Transmission of trained immunity and heterologous resistance to infections across generations

October 18, 2021

Nature Immunology, Published online: 18 October 2021; doi:10.1038/s41590-021-01052-7Transgenerational transmission of acquired immunological traits has been demonstrated in invertebrates and plants...

Circadian clocks guide dendritic cells into skin lymphatics

October 18, 2021

Nature Immunology, Published online: 18 October 2021; doi:10.1038/s41590-021-01040-xScheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin...

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

October 18, 2021

Nature Immunology, Published online: 18 October 2021; doi:10.1038/s41590-021-01035-8The antiviral factor ISG15 can be conjugated to other proteins through ISGylation. Sanyal and colleagues find that...

Reimagining an immunological dogma

October 18, 2021

Nature Immunology, Published online: 18 October 2021; doi:10.1038/s41590-021-01046-5Infections are known to induce epigenetic rewiring in myeloid cells, a phenomenon known as trained immunity, which...

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

October 6, 2021

Nature Immunology, Published online: 06 October 2021; doi:10.1038/s41590-021-01049-2Many babies have now been born to mothers who were exposed to SARS-CoV-2 during their pregnancy. Here the authors...