Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8<sup>+</sup> T cells

January 17, 2020

Nature Immunology, Published online: 17 January 2020; doi:10.1038/s41590-019-0584-xKohlmeier and colleagues showed that the airway environment drove transcriptional and epigenetic changes that...

The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity

January 13, 2020

Nature Immunology, Published online: 13 January 2020; doi:10.1038/s41590-019-0577-9Yin and colleagues show that the phosphatase PAC1 (DUSP2) acts as a checkpoint in cytotoxic T cells to restrain their...

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

January 13, 2020

Nature Immunology, Published online: 13 January 2020; doi:10.1038/s41590-019-0571-2Hidalgo and colleagues describe a cell-intrinsic program that induces changes in the proteome, granule content and...

Of larks and owls

January 13, 2020

Nature Immunology, Published online: 13 January 2020; doi:10.1038/s41590-019-0579-7A cell-intrinsic program induces circadian disarming of the toxic machinery of neutrophils in the steady state and...

T cell receptor and cytokine signal integration in CD8<sup>+</sup> T cells is mediated by the protein Themis

January 13, 2020

Nature Immunology, Published online: 13 January 2020; doi:10.1038/s41590-019-0570-3T cell homeostasis requires integration of signals from antigen and cytokine receptors. Gascoigne and colleagues...