Drugs for Metabolism Could Reverse Lupus

The study performed by the Morel Laboratory  provides compelling evidence that a combination of metabolic inhibitors could be an effective lupus therapy

A Clear Direction

Dr. Laurance Morel is the Director of the Experimental Pathology division at UF’s College of Medicine

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Lupus resistance is associated with marginal zone abnormalities in an NZM murine model

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Sometimes, it’s Lupus

Fictional character Dr. House is famous for proclaiming “It’s not Lupus,” but with 5 million Americans suffering from Lupus, it is certainly not an uncommon disease by an stretch of the imagination.

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Single-cell landscape of immunological responses in patients with COVID-19

August 12, 2020

Nature Immunology, Published online: 12 August 2020; doi:10.1038/s41590-020-0762-xSevere COVID-19 is characterized—among other things—by a hyperinflammatory state. Wang and colleagues describe the...

Author Correction: Novel Hexb-based tools for studying microglia in the CNS

August 11, 2020

Nature Immunology, Published online: 11 August 2020; doi:10.1038/s41590-020-0774-6Author Correction: Novel Hexb-based tools for studying microglia in the CNS

IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

August 10, 2020

Nature Immunology, Published online: 10 August 2020; doi:10.1038/s41590-020-0750-1Obesity is often accompanied by chronic inflammation. Li and colleagues show that, in mice fed high-fat diets, IL-1...

Hhex drives B cells down memory lane

August 7, 2020

Nature Immunology, Published online: 07 August 2020; doi:10.1038/s41590-020-0763-9The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal...

The mesenchymal context in inflammation, immunity and cancer

August 3, 2020

Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0741-2Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and...