Ying Yi Zheng: Predoctoral Fellow

I study how marginal zone B (MZB) cells in our lupus prone TC mice contribute to autoimmunity.  I am currently working on 2 aims for my porject.  For one aim, I want to determine whether the observed preferential expansion of MZB cells in TC mice is mediated by enhanced Notch2 signaling.  For the second aim, I am conducting cell transfer experiments to determine whether TC MZB cells are autoreactive in vivo.